Over accumulation of fluid in the interstitial space is generally bad and it affects the proper function of the tissue. This is because the formation of oedema increases the diffusion distance of oxygen and other nutrients. And for the same reason it reduces the diffusional removal of potentially toxic substances of cellular metabolism. This is especially important in the lungs where pulmonary oedema can greatly affect exchange of gasses. Also, certain anatomical structures limit tissue expansion in response to oedema. For example, the kidneys, brain, and the skeletal muscles (Scallan et al., 2010a). This means that small incremental changes in transcapillary fluid filtration will induce a large increase in interstitial fluid pressure.
Lack of calcium in the diet can lead to osteoporosis in which the bone is less dense and therefore brittle and weak. In women, osteoporosis can be due to lack of oestrogens after menopause or oophorectomy. Calcium is usually ubiquitous in diet, but often, a small amount of food provides reasonable amounts, of which dairy products are best.