WHAT MAKES COCAINE SO ADDICTIVE AND DANGEROUS?

Cocaine is a psychoactive alkaloid of the coca plant; it was originally used for local surgeries as an anaesthetic but has now become a recreational drug. Unlike amphetamines, which resemble the structural formula of dopamine and noradrenaline, cocaine has a similar structure to other synthetic sedatives. Cocaine is well absorbed when administered via the mucous membranes, the GI tract and IV route. Peak concentration happens within five minutes after intravenous injection, while the peak levels from smoking are usually reached within 60 minutes. Some cocaine is excreted in urine unchanged, the majority is metabolised into benzoylecgonine, ecgonine methyl ester, norcocaine and other metabolites. Although cocaine has a short half-life, the elimination half-life of the metabolites lasts longer. Studies also show that the half-life of cocaine may increase the longer it is used.

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An overview of the Clotting process

Hemostasis is a complex process that involves multiple interlinked steps. The aim of the cascade is to form a plug that closes the damaged site of the blood vessels, thereby controlling bleeding. It begins with injury in the lining of the blood vessels. The process can be split into four phases, this includes; constriction of the blood vessels, formation of the temporary platelet plug, activation of the coagulation cascade and formation of the fibrin plug or the final clot. There are numerous cells that are involved in the clotting cascade, most notably are the processes associated with the endothelium, platelets and hepatocytes (LaPelusa & Dave, 2020).

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An overview of the types and causes of Edema

Over accumulation of fluid in the interstitial space is generally bad and it affects the proper function of the tissue. This is because the formation of oedema increases the diffusion distance of oxygen and other nutrients. And for the same reason it reduces the diffusional removal of potentially toxic substances of cellular metabolism. This is especially important in the lungs where pulmonary oedema can greatly affect exchange of gasses. Also, certain anatomical structures limit tissue expansion in response to oedema. For example, the kidneys, brain, and the skeletal muscles (Scallan et al., 2010a). This means that small incremental changes in transcapillary fluid filtration will induce a large increase in interstitial fluid pressure.

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An overview of the inflammatory response

Inflammation is a pathological response that engages hundreds of mediators and different cells and tissue types. It can be initiated by any stimulus causing cell injury. Often the inflammation is a response to some sort of infection. In some cases, chemical or physical injury can also induce an inflammatory reaction. The goal of the inflammatory response is to remove the causative agent with minimal destruction to the body, and to repair the damage caused by the toxin. The duration of the inflammatory response is dependent on whether the causative agent has been eliminated. Acute inflammation is a relatively short process, lasting from minutes to a few day

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Structure of the Male Reproductive System

The male reproductive system includes the gonads, duct system, accessory glands, and the penis. The gonads are the testes, this is the site for sperm formation (spermatogenesis). The testis is located outside the body in the scrotum. Embryologically, the testes develop within the abdomen and usually descend about seven months during foetal development. If testes […]

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THE IMPORTANCE OF END-OF-LIFE PLANNING

Palliative care can be defined as an approach to health that involves improving the quality of life of patients and their families that are facing issues related to chronic, incurable and life-threatening illnesses (Wallerstedt et al., 2019). It is vital to note that, palliative care is not just limited to the elderly, but can be anyone with an incurable illness and the goal is to improve quality of life. The stages of palliative care include; stable, unstable, deteriorating, terminal and bereavement (McClelland et al., 2020).

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Why does child marriage happen?

According to World Vision, the most alarming statistic about child marriage is that almost 700 million women in the world today were married as girls. A third of them before there 15th birthday. Child marriage is a legal marriage or informal union where one or both parties are under the age of 18.

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Vitamin A and Vision

Vitamins are a diverse group of organic substances that are essential in the proper functioning of the metabolic processes in the body. Many vitamins, especially those found in the B group, work as coenzymes. Vitamin A is a name given to a group of fat-soluble retinoids, including retinol, retinal, and retinyl esters. Vitamin A is […]

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The Menstrual Cycle

The female reproductive system is made up of the gonads, duct system and accessory glands. It produces gametes and transports them for fertilisation. The process of birth and nurturing also happens in the female reproductive system. When the oocyte is matured, it is expelled from the ovaries and then travels down the fallopian tube, it passes […]

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The sonic hedgehog gene

The sonic hedgehog gene is the human form of the hedgehog superfamily of inductive molecules that play a role in the development of the embryo. Sonic hedgehog is necessary for the development of the front part of the brain. This signaling protein helps to establish the line that separates the right and left side of the forebrain. Sonic hedgehog also plays an important role in the formation of the eyes. During early development the cells that develop into the eye form a single structure called the eye field. The structure is found in the centre of the developing face. Sonic hedgehog signaling causes the eye field to separate into two distinct eyes (National Library of Medicine, 2020

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