Diseases Fitness Health

What Everyone Must Know About OBESITY

Obesity is a condition that is associated with excessive levels of body fat, obesity is considered a major health problem in Western Countries. Between 2014 and 2015 a staggering 63.4% of the population was overweight. This is an increase of 19% from 1995. In the same period, there was about 22,700 hospital separation involving one or more weight loss procedure, seven of eight of these procedures happened in private hospitals. 79% of these where for female patients. Figures also indicate that from 2005-2006 to 2014-25 weight loss surgeries more than doubled from about 9,300 to 22,700 (Gupta et al., 2016).

In Australia and other industrialised countries, there is a growing concern for the rising levels of childhood obesity. Recent figures indicate that 28% of children and adolescents are considered overweight or obese. In some minority groups, such as Aboriginal and Torres Strait Islanders, the figures appear to be even higher. In children, being overweight can lead to several short and long-term consequences. For example, low self-esteem, depression, body image issues and can increase the risk of individuals developing eating disorders (Sainsbury, Hendy, Magnusson, & Colagiuri, 2018).

    The World Health Organisation has classified obesity as a global epidemic. Overweight or obese people have higher rates of cardiovascular diseases, diabetes mellitus and cancer. Other problems that are associated with obesity include gastro-oesophageal reflux disease, sleep disorders and chronic joint pain. In some countries, the morbidity and mortality for obese people are second only to smoking cigarettes. The causes of obesity are complex and involve a combination of genetics, physiological and lifestyle factors.

      Regulation of Food Intake

  In humans there are two feeding centres which are both located in the hypothalamus, one is associated with hunger and stimulates eating. The other is associated with a sense of fullness and inhibits eating. The hunger centre is always active, but it is intermittently inhibited by the satiety centre. These centres respond to the noradrenaline signals, paracrine signals, blood nutrient levels and psychosocial factors. Stimuli that can trigger eating are numerous, for example, teste and smell, low blood sugar levels, some drugs such as marijuana and low ambient temperatures (Houben, Dassen, & Jansen, 2016).

    Another essential substance that regulates hunger is a hormone that is secreted by the stomach called Ghrelin. It helps to stimulate appetite, causing you to digest more food and store more fat. It also appears to help control insulin release and play a protective role in cardiovascular health. The levels of Ghrelin in the blood fluctuate during the day but are quite elevated prior to a meal and then decreases afterwards. Obese individuals tend to have lower levels of Ghrelin, whereas people with anorexia tend to have higher levels. What is interesting is that the speed to which Ghrelin drops can be influenced by the type of foods that are consumed (Pradhan, Samson, & Sun, 2013).

On the other hand, there are several chemical mediators that suppress appetite and reduce food intake. The monoamine neurotransmitter noradrenaline and serotonin tend to inhibit eating. Another hormone (CCK) is secreted in response to triglycerides in the gastrointestinal tract. It rapidly stimulates the satiety centres of the hypothalamus to stop eating. Some researchers have indicated that eating disorder like Bulimia may be associated with impaired CCK secretion (Al Shukor, Raes, Van Camp, & Smagghe, 2015).

Role of Leptin

    Leptin is a hormone that is released from the fat cells located in the adipose tissue, leptin helps regulate and alter long-term food intake and expenditure, not just from meal to meal. The primary design for leptin is to help the body maintain weight. Because leptin comes from the fat cells, the levels of leptin in an individual is directly connected to the fat composition of the body. If the individual ads fat the levels of leptin increase. Leptin helps inhibit hunger and regulate energy balance so that the body does not trigger hunger responses when the body needs energy. When the levels of leptin fall, as is the case in people who lose weight, it can trigger an increase in huge appetite and food cravings.

   In normal circumstances when the body is functioning well, excess fat cells will produce leptin which will trigger the hypothalamus to lower the appetite. This allows the body to deep into the fat stores to feed itself. In obese individuals, they have too much leptin in the blood. This can cause leptin resistance, where the body is no longer sensitive to the hormone. Low levels of leptin do happen, but this is rare, this is called congenital leptin deficiency. In Congenital leptin deficiency, the body does not produce leptin. And without leptin, the body thinks it has fat and this causes intense uncontrollable hunger and food intake. Congenital leptin deficiency often manifests in severe childhood obesity and delayed puberty (Park & Ahima, 2015).    

The internet is saturated with countless weight loss and super diet programs, each one of them promising faster weight loss results. But by far the best way to lose weight is by setting a sustainable and realistic program involving diet and exercise. Foods that should be avoided within reason and depending on your lifestyle are simple carbohydrates, processed sugars and processed meats. According to dietitians, sudden spurts of exercises use carbohydrate stores, whereas steady exercises use fat stores.

An Individual’s body mass is a product of their total energy intake and expenditure. An individual is said to be in energy balance when the food intake equals the energy that is consumed by the body cells. When this occurs, an individual will neither gain weight or lose weight. Assuming that the daily fluid intake and output stay the same.

Daily changes in the total energy intake and expenditure do happen, but if the individual manages to maintain this energy balance the total body weight will be maintained. The rate of energy expenditure determines the rate of usage by the body, it can be measured as oxygen consumption and body temperature. Factors that increase metabolism include physical activity, sympathetic nervous system stimulation and raised body temperature (Dhurandhar et al., 2015).

Suggestion for safe and effective weight loss

Do not crash diet, you will most likely regain the lost weight

Aim for small slow loses of around 1Kg per week

Cut down on dietary fats especially saturated fats and increase the general intake of fruits and vegetables.

Exercise at least three days a week, or generally increase your overall physical activity.


Al Shukor, N., Raes, K., Van Camp, J., & Smagghe, G. (2015). Analysis of interaction of phenolic compounds with the cholecystokinin signaling pathway to explain effects on reducing food intake. Paper presented at the 20th National symposium of Applied Biological Sciences (NSABS 2015).

Dhurandhar, N. V., Schoeller, D., Brown, A. W., Heymsfield, S. B., Thomas, D., Sørensen, T. I., . . . Group, E. B. M. W. (2015). Energy balance measurement: when something is not better than nothing. International Journal of Obesity, 39(7), 1109.

Gupta, N., Heiden, M., Aadahl, M., Korshøj, M., Jørgensen, M. B., & Holtermann, A. (2016). What is the effect on obesity indicators from replacing prolonged sedentary time with brief sedentary bouts, standing and different types of physical activity during working days? A cross-sectional accelerometer-based study among blue-collar workers. PLoS ONE, 11(5), e0154935.

Houben, K., Dassen, F. C., & Jansen, A. (2016). Taking control: Working memory training in overweight individuals increases self-regulation of food intake. Appetite, 105, 567-574.

Park, H.-K., & Ahima, R. S. (2015). Physiology of leptin: energy homeostasis, neuroendocrine function and metabolism. Metabolism, 64(1), 24-34.

Pradhan, G., Samson, S. L., & Sun, Y. (2013). Ghrelin: much more than a hunger hormone. Current opinion in clinical nutrition and metabolic care, 16(6), 619-624. doi:10.1097/MCO.0b013e328365b9be

Sainsbury, E., Hendy, C., Magnusson, R., & Colagiuri, S. (2018). Public support for government regulatory interventions for overweight and obesity in Australia. BMC Public Health, 18(1), 513.

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